Publications

Links are available on my Scholar page

Chauhan VP, Sharp PA, and Langer R (2024). Engineered prime editors with minimal genomic errors. Under review. Preprint on bioRxiv, www.biorxiv.org/content/10.1101/2024.08.02.606370v1 

Chauhan VP, Sharp PA, and Langer R (2023). Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases. Proceedings of the National Academy of Sciences USA, 120 (11): e2300605120.

Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, and Jain RK (2022). Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. Clinical Cancer Research, 28 (14): 3076-3090.

Ho WH, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, and Jain RK (2021). Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proceedings of the National Academy of Sciences USA, 118 (45): e2105323118.

Rybakova Y, Gonzalez JT, Bogorad R, Chauhan VP, Dong YL, Whittaker CA, Zatsepin T, Koteliansky V, and Anderson DG (2021). Identification of a long non-coding RNA regulator of liver carcinoma cell survival. Cell Death and Disease, 12 (2): 1-14.

Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Boucher Y, Kohane DS, Langer R, and Jain RK (2019). Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proceedings of the National Academy of Sciences USA, 116 (22): 10674-10680.

Chen IX, Chauhan VP, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Posada J, Lindeman N, Langer R, and Jain RK (2019). Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proceedings of the National Academy of Sciences USA, 116 (10): 4558-4566.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari NN, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Grodzinsky AJ, Baish JW, Munn LL, and Jain RK (2016). Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering, 0004. 

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, and Jain RK (2016). Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discovery, 6:852-859.

Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, and Jain RK (2014). Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell, 26:14-15.

Chauhan VP and Jain RK (2013). Strategies for advancing cancer nanomedicine. Nature Materials, 12:958-962

Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin S, Stylianopoulos T, Mousa A, Han X, Adstamongkonkul P, Popović Z, Huang P, Bawendi MG, Boucher Y, and Jain RK (2013). Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels. Nature Communications, 4:2516

Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, and Bawendi MG (2013). Compact high-quality CdSe–CdS core–shell nanocrystals with narrow emission linewidths and suppressed blinking. Nature Materials, 12 (5):445-451.

Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, and Jain RK (2012). Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences USA, 109 (38):15101-15108.

Chauhan VP, Stylianopoulos T, Martin JD, Popović Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK (2012). Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnology, 7 (6): 383-388.

Chauhan VP, Popović Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK (2011). Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angewandte Chemie, 123 (48): 11619-11622.

Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK (2011). Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annual Review of Chemical and Biomolecular Engineering, 2: 281-298.

Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson R, Jain RK (2011). Dehydro-α-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences USA, 108 (28): 11596-11601.

Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK (2011). Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proceedings of the National Academy of Sciences USA, 108 (7): 2909-2914.

Wong CR, Stylianopoulos T, Cui J, Martin JD, Chauhan VP, Jiang W, Popović Z, Jain RK, Bawendi MG, Fukumura D (2011). Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proceedings of the National Academy of Sciences USA, 108 (6): 2426-2431.

Popović Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG (2010). A nanoparticle size series for in vivo fluorescence imaging. Angewandte Chemie, 122 (46): 8649-8652.

Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG (2010). InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared. Journal of the American Chemical Society, 132 (2): 470-471.

Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK (2009). Multiscale diffusion measurements uncover the cellular and interstitial contributions to molecular hindrance in vivo. Biophysical Journal, 97 (1): 330-336.

Jain RK, Martin JD, Chauhan VP, and Duda DG. “Vascular and Interstitial Biology of Tumors,” in Abeloff’s Clinical Oncology. Sixth edition. Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, and Tepper JE, Editors. Churchill Livingstone, 2019.

Jain RK, Chauhan VP, and Duda DG. “Vascular and Interstitial Biology of Tumors,” in Abeloff’s Clinical Oncology. Fifth edition. Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, and Tepper JE, Editors. Churchill Livingstone, 2014. 108-126.

Chauhan VP, Sharp PA, and Langer R, inventors. Engineered Nucleases and Methods of Use Thereof. PCT/US18/069,387

Blume-Jensen P, Chickering DE, Kopesky PW, Reiter LA, Crane AL, Langer R, Tong R, Jain RK, Chauhan VP, Incio J, and Fukumura D, inventors. Polyacetal polymers, conjugates, particles and uses thereof. PCT/US2016/067149

Jain RK, Boucher Y, Chauhan VP, Diop-Frimpong B, Krane S, Crane AL, and Langer R, inventors. Novel compositions and uses of anti-hypertension agents for cancer therapy. PCT/US2011/061510